MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca(2+) Stress

Mitochondria shape cytosolic calcium ([Ca(2+)](c)) transients and utilize the mitochondrial Ca(2+) ([Ca(2+)](m)) in exchange for bioenergetics output. Conversely, dys-regulated [Ca(2+)](c) causes [Ca(2+)](m) overload and induces permeability transition pore and cell death. Ablation of MCU-mediated C...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Nemani, Neeharika, Carvalho, Edmund, Tomar, Dhanendra, Dong, Zhiwei, Ketschek, Andrea, Breves, Sarah L., Jaña, Fabián, Worth, Alison M., Heffler, Julie, Palaniappan, Palaniappan, Tripathi, Aparna, Subbiah, Ramasamy, Riitano, Massimo F., Seelam, Ajay, Manfred, Thomas, Itoh, Kie, Meng, Shuxia, Sesaki, Hiromi, Craigen, William J., Rajan, Sudarsan, Shanmughapriya, Santhanam, Caplan, Jeffrey, Prosser, Benjamin L., Gill, Donald L., Stathopulos, Peter B., Gallo, Gianluca, Chan, David C., Mishra, Prashant, Madesh, Muniswamy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973819/
https://ncbi.nlm.nih.gov/pubmed/29694881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.098
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