TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

Antiretroviral therapy (ART) can halt HIV-1 replication but fails to target the long-lived latent viral reservoir. Several pharmacological compounds have been evaluated for their ability to reverse HIV-1 latency, but none has demonstrably reduced the latent HIV-1 reservoir or affected viral rebound...

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Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Lim, So-Yon, Osuna, Christa E., Hraber, Peter T., Hesselgesser, Joe, Gerold, Jeffrey M., Barnes, Tiffany L., Sanisetty, Srisowmya, Seaman, Michael S., Lewis, Mark G., Geleziunas, Romas, Miller, Michael D., Cihlar, Tomas, Lee, William A., Hill, Alison L., Whitney, James B.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973480/
https://ncbi.nlm.nih.gov/pubmed/29720451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao4521
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