TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia

Reduction/elimination of HIV-1 reservoirs that persist despite combination antiretroviral therapy (cART) will likely require induction of viral expression by residual infected cells and enhanced clearance of these cells. TLR7 agonists have potential to mediate these activities. We evaluated immunolo...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Del Prete, Gregory Q., Alvord, W. Gregory, Li, Yuan, Deleage, Claire, Nag, Mukta, Oswald, Kelli, Thomas, James A., Pyle, Cathi, Bosche, William J., Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Berkemeier, Brian, Hull, Michael, Chipriano, Elizabeth, Silipino, Lorna, Fast, Randy, Kiser, Jacob, Kiser, Rebecca, Malys, Tyler, Kramer, Joshua, Breed, Matthew W., Trubey, Charles M., Estes, Jacob D., Barnes, Tiffany L., Hesselgesser, Joseph, Geleziunas, Romas, Lifson, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629134/
https://ncbi.nlm.nih.gov/pubmed/31167974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127717
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