Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy

The effectiveness of virus-specific strategies, including administered HIV-specific mAbs, to target cells that persistently harbor latent, rebound-competent HIV genomes during combination antiretroviral therapy (cART) has been limited by inefficient induction of viral protein expression. To examine...

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Publicado en:J Clin Invest
Autores principales: Swanstrom, Adrienne E., Immonen, Taina T., Oswald, Kelli, Pyle, Cathi, Thomas, James A., Bosche, William J., Silipino, Lorna, Hull, Michael, Newman, Laura, Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Kiser, Jacob, Morcock, David R., Shoemaker, Rebecca, Fast, Randy, Breed, Matthew W., Kramer, Joshua, Donohue, Duncan, Malys, Tyler, Fennessey, Christine M., Trubey, Charles M., Deleage, Claire, Estes, Jacob D., Lifson, Jeffrey D., Keele, Brandon F., Del Prete, Gregory Q.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954603/
https://ncbi.nlm.nih.gov/pubmed/33465055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142421
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