Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy

The effectiveness of virus-specific strategies, including administered HIV-specific mAbs, to target cells that persistently harbor latent, rebound-competent HIV genomes during combination antiretroviral therapy (cART) has been limited by inefficient induction of viral protein expression. To examine...

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Publié dans:J Clin Invest
Auteurs principaux: Swanstrom, Adrienne E., Immonen, Taina T., Oswald, Kelli, Pyle, Cathi, Thomas, James A., Bosche, William J., Silipino, Lorna, Hull, Michael, Newman, Laura, Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Kiser, Jacob, Morcock, David R., Shoemaker, Rebecca, Fast, Randy, Breed, Matthew W., Kramer, Joshua, Donohue, Duncan, Malys, Tyler, Fennessey, Christine M., Trubey, Charles M., Deleage, Claire, Estes, Jacob D., Lifson, Jeffrey D., Keele, Brandon F., Del Prete, Gregory Q.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954603/
https://ncbi.nlm.nih.gov/pubmed/33465055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142421
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