Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

BACKGROUND: Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNA(Lys3) to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNA(Lys3) is not the only molecule capable of priming reverse transcription, and t...

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Publicado en:Retrovirology
Autores principales: Fennessey, Christine M., Camus, Celine, Immonen, Taina T., Reid, Carolyn, Maldarelli, Frank, Lifson, Jeffrey D., Keele, Brandon F.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450007/
https://ncbi.nlm.nih.gov/pubmed/30947720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-019-0473-2
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