TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia

Reduction/elimination of HIV-1 reservoirs that persist despite combination antiretroviral therapy (cART) will likely require induction of viral expression by residual infected cells and enhanced clearance of these cells. TLR7 agonists have potential to mediate these activities. We evaluated immunolo...

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發表在:JCI Insight
Main Authors: Del Prete, Gregory Q., Alvord, W. Gregory, Li, Yuan, Deleage, Claire, Nag, Mukta, Oswald, Kelli, Thomas, James A., Pyle, Cathi, Bosche, William J., Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Berkemeier, Brian, Hull, Michael, Chipriano, Elizabeth, Silipino, Lorna, Fast, Randy, Kiser, Jacob, Kiser, Rebecca, Malys, Tyler, Kramer, Joshua, Breed, Matthew W., Trubey, Charles M., Estes, Jacob D., Barnes, Tiffany L., Hesselgesser, Joseph, Geleziunas, Romas, Lifson, Jeffrey D.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629134/
https://ncbi.nlm.nih.gov/pubmed/31167974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127717
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