TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia

Reduction/elimination of HIV-1 reservoirs that persist despite combination antiretroviral therapy (cART) will likely require induction of viral expression by residual infected cells and enhanced clearance of these cells. TLR7 agonists have potential to mediate these activities. We evaluated immunolo...

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Vydáno v:JCI Insight
Hlavní autoři: Del Prete, Gregory Q., Alvord, W. Gregory, Li, Yuan, Deleage, Claire, Nag, Mukta, Oswald, Kelli, Thomas, James A., Pyle, Cathi, Bosche, William J., Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Berkemeier, Brian, Hull, Michael, Chipriano, Elizabeth, Silipino, Lorna, Fast, Randy, Kiser, Jacob, Kiser, Rebecca, Malys, Tyler, Kramer, Joshua, Breed, Matthew W., Trubey, Charles M., Estes, Jacob D., Barnes, Tiffany L., Hesselgesser, Joseph, Geleziunas, Romas, Lifson, Jeffrey D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629134/
https://ncbi.nlm.nih.gov/pubmed/31167974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127717
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