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Tracking the Cartoon mouse phenotype: Hemopexin domain–dependent regulation of MT1-MMP pericellular collagenolytic activity

Following ENU mutagenesis, a phenodeviant line was generated, termed the “Cartoon mouse,” that exhibits profound defects in growth and development. Cartoon mice harbor a single S466P point mutation in the MT1-MMP hemopexin domain, a 200-amino acid segment that is thought to play a critical role in r...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Sakr, Moustafa, Li, Xiao-Yan, Sabeh, Farideh, Feinberg, Tamar Y., Tesmer, John J. G., Tang, Yi, Weiss, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971454/
https://ncbi.nlm.nih.gov/pubmed/29643184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001503
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