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Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers

In acute and chronic lung disease, widespread disruption of tissue architecture underlies compromised pulmonary function. Pulmonary fibroblasts have been implicated as critical effectors of tissue-destructive extracellular matrix (ECM) remodeling by mobilizing a spectrum of proteolytic enzymes. Alth...

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Detalhes bibliográficos
Main Authors: Grant Rowe, R., Keena, Daniel, Sabeh, Farideh, Willis, Amanda L., Weiss, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213981/
https://ncbi.nlm.nih.gov/pubmed/21840960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00187.2011
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