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Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone–Neomycin Conjugates

The antibacterial effects of aminoglycosides are based on their association with the A-site of bacterial rRNA and interference with the translational process in the bacterial cell, causing cell death. The clinical use of aminoglycosides is complicated by resistance and side effects, some of which ar...

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Dades bibliogràfiques
Publicat a:ACS Infect Dis
Autors principals: Degtyareva, Natalya N., Gong, Changjun, Story, Sandra, Levinson, Nathanael S., Oyelere, Adegboyega K., Green, Keith D., Garneau-Tsodikova, Sylvie, Arya, Dev P.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971063/
https://ncbi.nlm.nih.gov/pubmed/28103015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00176
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