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Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity
The nucleotides comprising the ribosomal decoding center are highly conserved, as they are important for maintaining translational fidelity. The bacterial A-site has a small base variation as compared with the human analogue, allowing aminoglycoside (AG) antibiotics to selectively bind within this r...
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| Publicado no: | Medchemcomm |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4722958/ https://ncbi.nlm.nih.gov/pubmed/26811742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5MD00427F |
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