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Neomycin-Neomycin Dimer: An All Carbohydrate Scaffold with High Affinity for AT Rich DNA Duplexes

A dimeric neomycin-neomycin conjugate 3 with a flexible linker, 2,2’-(Ethylenedioxy)bis(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT rich DNA duplexes with high affinity. Biophysical studies have been performed between 3 and different nucleic acids with var...

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Bibliografski detalji
Glavni autori: Kumar, Sunil, Xue, Liang, Arya, Dev P.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641821/
https://ncbi.nlm.nih.gov/pubmed/21524066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja108118v
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