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Influence of Linker Length and Composition on Enzymatic Activity and Ribosomal Binding of Neomycin Dimers
The human and bacterial A site rRNA binding as well as the aminoglycoside-modifying enzyme (AME) activity against a series of neomycin B (NEO) dimers is presented. The data indicate that by simple modifications of linker length and composition, substantial differences in rRNA selectivity and AME act...
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| Vydáno v: | Antimicrob Agents Chemother |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468663/ https://ncbi.nlm.nih.gov/pubmed/25896697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00861-15 |
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