In vivo reprogramming drives Kras-induced cancer development

The faithful shutdown of the somatic program occurs in the early stage of reprogramming. Here, we examined the effect of in vivo reprogramming on Kras-induced cancer development. We show that the transient expression of reprogramming factors (1–3 days) in pancreatic acinar cells results in the trans...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Shibata, Hirofumi, Komura, Shingo, Yamada, Yosuke, Sankoda, Nao, Tanaka, Akito, Ukai, Tomoyo, Kabata, Mio, Sakurai, Satoko, Kuze, Bunya, Woltjen, Knut, Haga, Hironori, Ito, Yatsuji, Kawaguchi, Yoshiya, Yamamoto, Takuya, Yamada, Yasuhiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970190/
https://ncbi.nlm.nih.gov/pubmed/29802314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04449-5
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