Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

Clear cell sarcoma (CCS) is a rare soft tissue sarcoma caused by the EWS/ATF1 fusion gene. Here, we established induced pluripotent stem cells (iPSCs) from EWS/ATF1-controllable murine CCS cells harboring sarcoma-associated genetic abnormalities. Sarcoma-iPSC mice develop secondary sarcomas immediat...

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Publicado no:Nat Commun
Main Authors: Komura, Shingo, Ito, Kenji, Ohta, Sho, Ukai, Tomoyo, Kabata, Mio, Itakura, Fumiaki, Semi, Katsunori, Matsuda, Yutaka, Hashimoto, Kyoichi, Shibata, Hirofumi, Sone, Masamitsu, Jo, Norihide, Sekiguchi, Kazuya, Ohno, Takatoshi, Akiyama, Haruhiko, Shimizu, Katsuji, Woltjen, Knut, Ozawa, Manabu, Toguchida, Junya, Yamamoto, Takuya, Yamada, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728361/
https://ncbi.nlm.nih.gov/pubmed/31488818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11745-1
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