Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are potent antitumor agents, how nature constructs their complex structures remains poorly understood. Herein, we report the discovery of a number...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, De, Bidhan Chandra, Zhu, Yiguang, Jiang, Xiaodong, Fang, Chunyan, Zhang, Qingbo, Yuan, Cheng-Shan, Liu, Hung-wen, Zhang, Changsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970136/
https://ncbi.nlm.nih.gov/pubmed/29802272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04487-z
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