Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U

Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening by EHs remains challenging. Alp1U is an α/β-fold EH...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhang, Liping, De, Bidhan Chandra, Zhang, Wenjun, Mándi, Attila, Fang, Zhuangjie, Yang, Chunfang, Zhu, Yiguang, Kurtán, Tibor, Zhang, Changsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863881/
https://ncbi.nlm.nih.gov/pubmed/33004437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015563
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