Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U

Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening by EHs remains challenging. Alp1U is an α/β-fold EH...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Zhang, Liping, De, Bidhan Chandra, Zhang, Wenjun, Mándi, Attila, Fang, Zhuangjie, Yang, Chunfang, Zhu, Yiguang, Kurtán, Tibor, Zhang, Changsheng
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863881/
https://ncbi.nlm.nih.gov/pubmed/33004437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015563
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares