Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are potent antitumor agents, how nature constructs their complex structures remains poorly understood. Herein, we report the discovery of a number...

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Vydáno v:Nat Commun
Hlavní autoři: Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, De, Bidhan Chandra, Zhu, Yiguang, Jiang, Xiaodong, Fang, Chunyan, Zhang, Qingbo, Yuan, Cheng-Shan, Liu, Hung-wen, Zhang, Changsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970136/
https://ncbi.nlm.nih.gov/pubmed/29802272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04487-z
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