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Engineering Anthracycline Biosynthesis toward Angucyclines
The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic biosynthesis gene cluster. Addition of pgaF to a gene cassette that harbored the early biosynthesis gene...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC152523/ https://ncbi.nlm.nih.gov/pubmed/12654660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1291-1296.2003 |
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