Engineering Anthracycline Biosynthesis toward Angucyclines

The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic biosynthesis gene cluster. Addition of pgaF to a gene cassette that harbored the early biosynthesis gene...

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Detaylı Bibliyografya
Asıl Yazarlar: Metsä-Ketelä, Mikko, Palmu, Kaisa, Kunnari, Tero, Ylihonko, Kristiina, Mäntsälä, Pekka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2003
Konular:
Chemistry; Biosynthesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC152523/
https://ncbi.nlm.nih.gov/pubmed/12654660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1291-1296.2003
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