Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater

Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene snoaL, encoding a nogalonic acid methyl ester cyclase for nogalamycin, was used to generate nog...

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Detaylı Bibliyografya
Asıl Yazarlar: Torkkell, Sirke, Kunnari, Tero, Palmu, Kaisa, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2000
Konular:
Chemistry; Biosynthesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC89689/
https://ncbi.nlm.nih.gov/pubmed/10639368
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