Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater

Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene snoaL, encoding a nogalonic acid methyl ester cyclase for nogalamycin, was used to generate nog...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Torkkell, Sirke, Kunnari, Tero, Palmu, Kaisa, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Chemistry; Biosynthesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.2.396-399.2000
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