Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines

Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of producing improved derivatives with reduced side effec...

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Principais autores:	Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Bioengineering and Biotechnology
Assuntos:	doxorubicin anthracyclines anticancer metabolic engineering biosynthesis Streptomyces
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fbioe.2024.1363803/full
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