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Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities
Comparison of homologous angucycline modification enzymes from five closely related Streptomyces pathways (pga, cab, jad, urd, lan) allowed us to deduce the biosynthetic steps responsible for the three alternative outcomes, gaudimycin C, dehydrorabelomycin and 11-deoxylandomycinone. The C-12b-hydrox...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361699/ https://ncbi.nlm.nih.gov/pubmed/22633416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.010 |
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