Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities

Comparison of homologous angucycline modification enzymes from five closely related Streptomyces pathways (pga, cab, jad, urd, lan) allowed us to deduce the biosynthetic steps responsible for the three alternative outcomes, gaudimycin C, dehydrorabelomycin and 11-deoxylandomycinone. The C-12b-hydrox...

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Autori principali: Patrikainen, Pekka, Kallio, Pauli, Fan, Keqiang, Klika, Karel D., Shaaban, Khaled A., Mäntsälä, Pekka, Rohr, Jürgen, Yang, Keqian, Niemi, Jarmo, Metsä-Ketelä, Mikko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361699/
https://ncbi.nlm.nih.gov/pubmed/22633416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.010
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