Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities

Comparison of homologous angucycline modification enzymes from five closely related Streptomyces pathways (pga, cab, jad, urd, lan) allowed us to deduce the biosynthetic steps responsible for the three alternative outcomes, gaudimycin C, dehydrorabelomycin and 11-deoxylandomycinone. The C-12b-hydrox...

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Detalhes bibliográficos
Main Authors: Patrikainen, Pekka, Kallio, Pauli, Fan, Keqiang, Klika, Karel D., Shaaban, Khaled A., Mäntsälä, Pekka, Rohr, Jürgen, Yang, Keqian, Niemi, Jarmo, Metsä-Ketelä, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361699/
https://ncbi.nlm.nih.gov/pubmed/22633416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.010
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