Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities

Comparison of homologous angucycline modification enzymes from five closely related Streptomyces pathways (pga, cab, jad, urd, lan) allowed us to deduce the biosynthetic steps responsible for the three alternative outcomes, gaudimycin C, dehydrorabelomycin and 11-deoxylandomycinone. The C-12b-hydrox...

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Detaylı Bibliyografya
Asıl Yazarlar: Patrikainen, Pekka, Kallio, Pauli, Fan, Keqiang, Klika, Karel D., Shaaban, Khaled A., Mäntsälä, Pekka, Rohr, Jürgen, Yang, Keqian, Niemi, Jarmo, Metsä-Ketelä, Mikko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361699/
https://ncbi.nlm.nih.gov/pubmed/22633416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.010
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