Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities

Comparison of homologous angucycline modification enzymes from five closely related Streptomyces pathways (pga, cab, jad, urd, lan) allowed us to deduce the biosynthetic steps responsible for the three alternative outcomes, gaudimycin C, dehydrorabelomycin and 11-deoxylandomycinone. The C-12b-hydrox...

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Main Authors: Patrikainen, Pekka, Kallio, Pauli, Fan, Keqiang, Klika, Karel D., Shaaban, Khaled A., Mäntsälä, Pekka, Rohr, Jürgen, Yang, Keqian, Niemi, Jarmo, Metsä-Ketelä, Mikko
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361699/
https://ncbi.nlm.nih.gov/pubmed/22633416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.010
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