Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are potent antitumor agents, how nature constructs their complex structures remains poorly understood. Herein, we report the discovery of a number...

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Publicat a:Nat Commun
Autors principals: Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, De, Bidhan Chandra, Zhu, Yiguang, Jiang, Xiaodong, Fang, Chunyan, Zhang, Qingbo, Yuan, Cheng-Shan, Liu, Hung-wen, Zhang, Changsheng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970136/
https://ncbi.nlm.nih.gov/pubmed/29802272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04487-z
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