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Synthesis of C‐14 labeled GABA(A) α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABA(A) receptor modulator AZD7325
Anxiolytic activity has been associated with GABA(A) α2 and α3 subunits. Several target compounds were identified and required in C‐14 labeled form to enable a better understanding of their drug metabolism and pharmacokinetic properties. AZD7325 is a selective GABA(A) α2 and α3 receptor modulator in...
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| Publicado no: | J Labelled Comp Radiopharm |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5969218/ https://ncbi.nlm.nih.gov/pubmed/29314165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3602 |
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