Synthesis and positron emission tomography studies of C-11 labeled isotopomers and metabolites of GTS-21, a partial α7 nicotinic cholinergic agonist drug

INTRODUCTION: GTS-21 ((3E)-3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3′-bipyridine), a partial α7 nicotinic acetylcholine receptor agonist drug, has recently been shown to improve cognition in schizophrenia and Alzheimer’s disease. One of its two major demethylated metabolites, 4-OH-GT...

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Detalhes bibliográficos
Main Authors: Kim, Sung Won, Ding, Yu-Shin, Alexoff, David, Patel, Vinal, Logan, Jean, Lin, Kuo-Shyan, Shea, Colleen, Muench, Lisa, Xu, Youwen, Carter, Pauline, King, Payton, Constanzo, Jasmine R., Ciaccio, James A., Fowler, Joanna S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182824/
https://ncbi.nlm.nih.gov/pubmed/17591554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2007.04.005
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