Reinvestigation of the Synthesis and Evaluation of [N-methyl-(11)C]Vorozole, a Radiotracer Targeting Cytochrome P450 Aromatase

INTRODUCTION: We reinvestigated the synthesis of [N-methyl-(11)C]vorozole, a radiotracer for aromatase, and discovered the presence of an N-methyl isomer which was not removed in the original purification method. Herein we report the preparation and PET studies of pure [N-methyl-(11)C]vorozole. METH...

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Autori principali: Kim, Sung Won, Biegon, Anat, Katsamanis, Zachary E., Ehrlich, Carolin W., Hooker, Jacob M., Shea, Colleen, Muench, Lisa, Xu, Youwen, King, Payton, Carter, Pauline, Alexoff, David L., Fowler, Joanna S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693459/
https://ncbi.nlm.nih.gov/pubmed/19324278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2008.12.013
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