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Evaluation of [(11)C]Metergoline as a PET Radiotracer for 5HTR in Nonhuman Primates

Metergoline, a serotonin receptor antagonist, was labeled with carbon-11 in order to evaluate pharmacokinetics and distribution in non-human primates using positron emission tomography. [(11)C]Metergoline had moderate brain uptake and exhibited heterogeneous specific binding which was blocked by pre...

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Detalhes bibliográficos
Main Authors: Hooker, Jacob M., Kim, Sung Won, Reibel, Achim T., Alexoff, David, Xu, Youwen, Shea, Colleen
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951501/
https://ncbi.nlm.nih.gov/pubmed/20451398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.04.039
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