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Evaluation of [(11)C]Metergoline as a PET Radiotracer for 5HTR in Nonhuman Primates
Metergoline, a serotonin receptor antagonist, was labeled with carbon-11 in order to evaluate pharmacokinetics and distribution in non-human primates using positron emission tomography. [(11)C]Metergoline had moderate brain uptake and exhibited heterogeneous specific binding which was blocked by pre...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951501/ https://ncbi.nlm.nih.gov/pubmed/20451398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.04.039 |
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