The central nervous system effects of the partial GABA-Aα(2,3)-selective receptor modulator AZD7325 in comparison with lorazepam in healthy males

AIMS: AZD7325 is a novel α(2,3)-subtype-selective partial GABA-A-receptor modulator. This study investigated the pharmacodynamics of single oral doses of AZD7325 2 mg and 10 mg on the central nervous system (CNS) compared with placebo and lorazepam 2 mg. METHODS: This double-blind, randomized, four...

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Udgivet i:Br J Clin Pharmacol
Main Authors: Chen, Xia, Jacobs, Gabriël, de Kam, Marieke, Jaeger, Judith, Lappalainen, Jaakko, Maruff, Paul, Smith, Mark A, Cross, Alan J, Cohen, Adam, van Gerven, Joop
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Clinical Trials
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256620/
https://ncbi.nlm.nih.gov/pubmed/24802722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12413
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