Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in patient-derived GBM neural stem cells (GNS) to determine the effects on proliferation and survival. Compounds that modulate do...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Dolma, Sonam, Selvadurai, Hayden J., Lan, Xiaoyang, Lee, Lilian, Kushida, Michelle, Voisin, Veronique, Whetstone, Heather, So, Milly, Aviv, Tzvi, Park, Nicole, Zhu, Xueming, Xu, ChangJiang, Head, Renee, Rowland, Katherine J., Bernstein, Mark, Clarke, Ian D., Bader, Gary, Harrington, Lea, Brumell, John H., Tyers, Mike, Dirks, Peter B.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968455/
https://ncbi.nlm.nih.gov/pubmed/27300435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.002
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