Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in patient-derived GBM neural stem cells (GNS) to determine the effects on proliferation and survival. Compounds that modulate do...

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Vydáno v:Cancer Cell
Hlavní autoři: Dolma, Sonam, Selvadurai, Hayden J., Lan, Xiaoyang, Lee, Lilian, Kushida, Michelle, Voisin, Veronique, Whetstone, Heather, So, Milly, Aviv, Tzvi, Park, Nicole, Zhu, Xueming, Xu, ChangJiang, Head, Renee, Rowland, Katherine J., Bernstein, Mark, Clarke, Ian D., Bader, Gary, Harrington, Lea, Brumell, John H., Tyers, Mike, Dirks, Peter B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968455/
https://ncbi.nlm.nih.gov/pubmed/27300435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.002
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