NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest

Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome. However, the importance of individual receptors in TNBC and their specific mechanism of action remain to be elucidated, even...

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Foilsithe in:Oncogenesis
Main Authors: Diluvio, Giulia, Del Gaudio, Francesca, Giuli, Maria Valeria, Franciosa, Giulia, Giuliani, Eugenia, Palermo, Rocco, Besharat, Zein Mersini, Pignataro, Maria Gemma, Vacca, Alessandra, d’Amati, Giulia, Maroder, Marella, Talora, Claudio, Capalbo, Carlo, Bellavia, Diana, Checquolo, Saula
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968025/
https://ncbi.nlm.nih.gov/pubmed/29795369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0051-9
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