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Novel isoguanine derivative of unlocked nucleic acid—Investigations of thermodynamics and biological potential of modified thrombin binding aptamer
Thrombin binding aptamer (TBA), is a short DNA 15-mer that forms G-quadruplex structure and possesses anticoagulant properties. Some chemical modifications, including unlocked nucleic acids (UNA), 2′-deoxy-isoguanosine and 2′-deoxy-4-thiouridine were previously found to enhance the biological activi...
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| Published in: | PLoS One |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967839/ https://ncbi.nlm.nih.gov/pubmed/29795635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197835 |
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