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Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer
A 15-mer DNA aptamer (named TBA) adopts a G-quadruplex structure that strongly inhibits fibrin-clot formation by binding to thrombin. We have performed thermodynamic analysis, binding affinity and biological activity studies of TBA variants modified by unlocked nucleic acid (UNA) monomers. UNA-U pla...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035450/ https://ncbi.nlm.nih.gov/pubmed/20870750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq823 |
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