Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparall...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Kotkowiak, Weronika, Lisowiec-Wachnicka, Jolanta, Grynda, Jakub, Kierzek, Ryszard, Wengel, Jesper, Pasternak, Anna
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862132/
https://ncbi.nlm.nih.gov/pubmed/29499943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.12.013
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker