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Identification of a rare COCH mutation by whole-exome sequencing: Implications for personalized therapeutic rehabilitation in an Austrian family with non-syndromic autosomal dominant late-onset hearing loss

BACKGROUND: Non-syndromic autosomal dominant hearing impairment is characteristically postlingual in onset. Genetic diagnostics are essential for genetic counselling, disease prognosis and understanding of the molecular mechanisms of disease. To date, 36 causative genes have been identified, many in...

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Vydáno v:Wien Klin Wochenschr
Hlavní autoři: Parzefall, Thomas, Frohne, Alexandra, Koenighofer, Martin, Kirchnawy, Andreas, Streubel, Berthold, Schoefer, Christian, Gstoettner, Wolfgang, Frei, Klemens, Lucas, Trevor
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Vienna 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966484/
https://ncbi.nlm.nih.gov/pubmed/28733840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00508-017-1230-y
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