Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase

New therapeutic options are needed for treatment of human African trypanosomiasis (HAT) caused by protozoan parasite Trypanosoma brucei. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine pathway of T. brucei. Previous attempts to target this enzyme were thwarted b...

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Publicado en:J Med Chem
Main Authors: Volkov, Oleg A., Brockway, Anthony J., Wring, Stephen A., Peel, Michael, Chen, Zhe, Phillips, Margaret A., De Brabander, Jef K.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965259/
https://ncbi.nlm.nih.gov/pubmed/29271204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01654
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