A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei

Polyamines are essential for cell growth of eukaryotes including the etiologic agent of human African trypanosomiasis (HAT), Trypanosoma brucei. In trypanosomatids, a key enzyme in the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylase (TbAdoMetDC) heterodimerizes with a unique catal...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Patel, Manish M., Volkov, Oleg A., Leija, Christopher, Lemoff, Andrew, Phillips, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221367/
https://ncbi.nlm.nih.gov/pubmed/30365568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007404
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