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Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme

Human African trypanosomiasis is caused by a single-celled protozoan parasite, Trypanosoma brucei. Polyamine biosynthesis is a clinically validated target for the treatment of human African trypanosomiasis. Metabolic differences between the parasite and the human polyamine pathway are thought to con...

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Autores principales: Velez, Nahir, Brautigam, Chad A., Phillips, Margaret A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576127/
https://ncbi.nlm.nih.gov/pubmed/23288847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.442475
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