Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase

The ataxia telangiectasia and Rad3-related (ATR) protein kinase promotes cancer cell survival by signaling stalled replication forks generated by replication stress, a common feature of many cancers including acute myeloid leukemia (AML). Here we show that the antileukemic activity of the chemothera...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Fordham, Sarah E., Blair, Helen J., Elstob, Claire J., Plummer, Ruth, Drew, Yvette, Curtin, Nicola J., Heidenreich, Olaf, Pal, Deepali, Jamieson, David, Park, Catherine, Pollard, John, Fields, Scott, Milne, Paul, Jackson, Graham H., Marr, Helen J., Menne, Tobias, Jones, Gail L., Allan, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965047/
https://ncbi.nlm.nih.gov/pubmed/29789314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017015214
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