Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

ATRis an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Middleton, Fiona K., Patterson, Miranda J., Elstob, Claire J., Fordham, Sarah, Herriott, Ashleigh, Wade, Mark A., McCormick, Aiste, Edmondson, Richard, May, Felicity E.B., Allan, James M., Pollard, John R., Curtin, Nicola J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741701/
https://ncbi.nlm.nih.gov/pubmed/26486089
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