Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

ATRis an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibi...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Middleton, Fiona K., Patterson, Miranda J., Elstob, Claire J., Fordham, Sarah, Herriott, Ashleigh, Wade, Mark A., McCormick, Aiste, Edmondson, Richard, May, Felicity E.B., Allan, James M., Pollard, John R., Curtin, Nicola J.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
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Priority Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741701/
https://ncbi.nlm.nih.gov/pubmed/26486089
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