Development of pharmacodynamic biomarkers for ATR inhibitors

BACKGROUND: ATR, which signals DNA damage to S/G2 cell cycle checkpoints and for repair, is an attractive target in cancer therapy. ATR inhibitors are being developed and a pharmacodynamic assay is needed to support clinical studies. METHODS: Phosphorylation of ATR targets, Chk1 and H2AX, was evalua...

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Publicat a:Mol Oncol
Autors principals: Chen, Tao, Middleton, Fiona K., Falcon, Susanna, Reaper, Philip M., Pollard, John R., Curtin, Nicola J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528661/
https://ncbi.nlm.nih.gov/pubmed/25459351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.012
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