α-Actinin Anchors PSD-95 at Postsynaptic Sites

Despite the central role PSD-95 plays in anchoring postsynaptic AMPARs, how PSD-95 itself is tethered to postsynaptic sites is not well understood. Here we show that the F-actin binding protein α-actinin binds to the very N-terminus of PSD-95. Knock-down (kd) of α-actinin phenocopies kd of PSD-95. M...

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Veröffentlicht in:Neuron
Hauptverfasser: Matt, Lucas, Kim, Karam, Hergarden, Anne E., Patriarchi, Tommaso, Malik, Zulfiqar A., Park, Deborah K., Chowdhury, Dhrubajyoti, Buonarati, Olivia R., Henderson, Peter B., Saraç, Çiğdem Gökçek, Zhang, Yonghong, Mohapatra, Durga, Horne, Mary C., Ames, James B., Hell, Johannes W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963734/
https://ncbi.nlm.nih.gov/pubmed/29429936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.01.036
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