α-Actinin Anchors PSD-95 at Postsynaptic Sites

Despite the central role PSD-95 plays in anchoring postsynaptic AMPARs, how PSD-95 itself is tethered to postsynaptic sites is not well understood. Here we show that the F-actin binding protein α-actinin binds to the very N-terminus of PSD-95. Knock-down (kd) of α-actinin phenocopies kd of PSD-95. M...

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Publié dans:Neuron
Auteurs principaux: Matt, Lucas, Kim, Karam, Hergarden, Anne E., Patriarchi, Tommaso, Malik, Zulfiqar A., Park, Deborah K., Chowdhury, Dhrubajyoti, Buonarati, Olivia R., Henderson, Peter B., Saraç, Çiğdem Gökçek, Zhang, Yonghong, Mohapatra, Durga, Horne, Mary C., Ames, James B., Hell, Johannes W.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963734/
https://ncbi.nlm.nih.gov/pubmed/29429936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.01.036
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