α-Actinin Anchors PSD-95 at Postsynaptic Sites

Despite the central role PSD-95 plays in anchoring postsynaptic AMPARs, how PSD-95 itself is tethered to postsynaptic sites is not well understood. Here we show that the F-actin binding protein α-actinin binds to the very N-terminus of PSD-95. Knock-down (kd) of α-actinin phenocopies kd of PSD-95. M...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Matt, Lucas, Kim, Karam, Hergarden, Anne E., Patriarchi, Tommaso, Malik, Zulfiqar A., Park, Deborah K., Chowdhury, Dhrubajyoti, Buonarati, Olivia R., Henderson, Peter B., Saraç, Çiğdem Gökçek, Zhang, Yonghong, Mohapatra, Durga, Horne, Mary C., Ames, James B., Hell, Johannes W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963734/
https://ncbi.nlm.nih.gov/pubmed/29429936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.01.036
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