Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies

T cells expressing second-generation chimeric antigen receptors (CARs) specific for CD5, a T-cell surface marker present on normal and malignant T cells, can selectively kill tumor cells. We aimed to improve this killing by substituting the CD28 costimulatory endodomain (28.z) with 4-1BB (BB.z), as...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Mamonkin, Maksim, Mukherjee, Malini, Srinivasan, Madhuwanti, Sharma, Sandhya, Gomes-Silva, Diogo, Mo, Feiyan, Krenciute, Giedre, Orange, Jordan S., Brenner, Malcolm K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963729/
https://ncbi.nlm.nih.gov/pubmed/29079655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0126
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