CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

Extending the success of chimeric antigen receptor (CAR) T cells to T-cell malignancies is problematic because most target antigens are shared between normal and malignant cells, leading to CAR T-cell fratricide. CD7 is a transmembrane protein highly expressed in acute T-cell leukemia (T-ALL) and in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Gomes-Silva, Diogo, Srinivasan, Madhuwanti, Sharma, Sandhya, Lee, Ciaran M., Wagner, Dimitrios L., Davis, Timothy H., Rouce, Rayne H., Bao, Gang, Brenner, Malcolm K., Mamonkin, Maksim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520470/
https://ncbi.nlm.nih.gov/pubmed/28539325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-01-761320
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