Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector Dependent

Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency. Incorporating 4-1BB costimulation in CARs may enable T cells to resist this functional exhaustion; however, the potential ramifications of tonic 4-...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Gomes-Silva, Diogo, Mukherjee, Malini, Srinivasan, Madhuwanti, Krenciute, Giedre, Dakhova, Olga, Zheng, Yueting, Cabral, Joaquim M. S., Rooney, Cliona M., Orange, Jordan S., Brenner, Malcolm K., Mamonkin, Maksim
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645034/
https://ncbi.nlm.nih.gov/pubmed/28978471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.015
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